Dapoxetine: An effective solution for ejaculation control.
Dapoxetine is a medication specifically designed to treat premature ejaculation (PE) in men. This comprehensive review covers all the key aspects of Dapoxetine, including its mechanism of action, how to take it, contraindications, possible side effects, and recommendations for purchasing it in the US.
Slippers Dapoxetine what is it?
Dapoxetine is a pill-based medication for oral use that helps men effectively combat the problem of premature ejaculation. It is the first and only approved drug for the treatment of PE “on demand”, meaning it is taken immediately before intercourse rather than on an ongoing basis. Dapoxetine allows men to significantly prolong the duration of intercourse, improve control over ejaculation, and experience greater pleasure from intimacy.
What is the composition of Dapoxetine?
The main active ingredient of the drug is dapoxetine hydrochloride . The dosage of dapoxetine in tablets can be different: 30 mg, 60 mg or 90 mg. Dapoxetine belongs to the group of selective serotonin reuptake inhibitors (SSRIs), but, unlike antidepressants of this group, it is designed specifically for the treatment of PE and has a short half-life. Its mechanism of action is to increase the concentration of serotonin in the synaptic cleft (the space between nerve cells) in certain areas of the central nervous system responsible for controlling ejaculation. This leads to a delay in ejaculation and an extension of the duration of sexual intercourse.
In addition to dapoxetine, the tablets contain excipients that ensure the stability of the drug, its proper dissolution and absorption by the body. These may include:
- Lactose monohydrate
- Microcrystalline cellulose
- Crosscarmellose sodium
- Silicon dioxide colloidal anhydrous
- Magnesium stearate
- Film coating (may contain hypromellose, titanium dioxide, macrogol, dyes)
Important! The exact composition of the excipients may vary depending on the manufacturer. Always read the information on the packaging and in the instructions for the drug.
Who is the manufacturer of Dapoxetine and what is a generic?
The original drug with dapoxetine was developed by Janssen-Cilag (a division of Johnson & Johnson) and is sold under the trade name Priligy .
A generic is a medicine that contains the same active ingredient as the original drug, but is produced by another pharmaceutical company after the patent for the original drug has expired. Generics undergo mandatory quality control and must meet the same standards of effectiveness and safety as original drugs.
There are many generics of dapoxetine on the market, which are manufactured by different pharmaceutical companies around the world, particularly in India. They may have different trade names (e.g. Duratia, Poxet, Stop Ejac), but contain dapoxetine as the main active ingredient. Generics are usually more affordable than the original drugs, while maintaining similar effectiveness.
Why take Dapoxetine?
Dapoxetine is indicated for the treatment of premature ejaculation (PE) in men aged 18 to 64 years. PE is defined as a condition in which ejaculation occurs earlier than desired by the man or his partner, leading to dissatisfaction with sexual life. Dapoxetine helps to solve this problem if it meets the following criteria:
- Ejaculation occurs consistently or intermittently before penetration or within about one minute after it.
- Feeling unable to control ejaculation.
- Negative personal consequences such as stress, frustration, avoidance of intimacy.
Dapoxetine helps:
- Extend the duration of sexual intercourse: The drug effectively delays the onset of ejaculation, allowing the man and his partner to enjoy intimacy longer.
- Improve control over ejaculation: Thanks to the action of dapoxetine, a man gets the opportunity to better control the moment of ejaculation.
- Increase self-confidence and reduce stress: Resolving the problem of PE has a positive effect on the psycho-emotional state of a man, increasing his self-esteem and self-confidence.
- Improve the quality of sexual life By prolonging sexual intercourse and improving control over ejaculation, dapoxetine helps to harmonize intimate relationships and increase pleasure from sex.
It is important to remember that dapoxetine is not an aphrodisiac and does not affect sexual desire. It also does not treat the causes of PE, but only helps control its symptoms.
How to take dapoxetine?
Dapoxetine is taken orally, 1-3 hours before the planned sexual intercourse, with a sufficient amount of water. The recommended starting dose is 30 mg . Depending on individual tolerance and effectiveness, the dose can be increased to 60 mg or left at 30 mg, but only after consulting a doctor . The maximum daily dose is 60 mg.
Important!
- Do not exceed the recommended daily dose.
- The drug is not intended for daily use. It should be taken only when needed before planned sexual intercourse.
- Do not take dapoxetine more than once every 24 hours.
Food intake does not affect the effectiveness of the drug, but drinking alcohol may reduce its effect and increase the risk of side effects.
What are the contraindications for Dapoxetine?
Dapoxetine has a number of contraindications, including:
- Individual intolerance to dapoxetine or any component of the drug.
- Severe heart disease such as heart failure, abnormal heart rhythm.
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or use of an MAOI within the last 14 days.
- Concomitant administration of thioridazine and other drugs that have a similar effect on liver enzymes and the cardiovascular system to thioridazine.
- Concomitant use of selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants and other drugs with serotonergic action or use of these drugs within the last 14 days
- Moderate and severe hepatic impairment.
- Age up to 18 years and over 64 years.
- Not intended for use in women.
- History of suicidal thoughts or behavior.
- History of manic episode.
- Epilepsy
Before starting to take dapoxetine, it is important to consult with your doctor, especially if you have chronic diseases, are taking other medications, or are unsure about your health.
Does Dapoxetine have side effects?
Dapoxetine, like any other medicine, can cause side effects. The most common of these are:
- Nausea
- Dizziness
- headache
- Diarrhea
- Insomnia
- Fatigue
- Dry mouth
These side effects are usually mild and temporary and go away on their own within a few hours.
Less commonly, more serious side effects may occur, such as:
- Fainting
- Orthostatic hypotension (a sharp decrease in blood pressure when changing body position)
- Depression
- Anxiety
- Excitation
- Allergic reactions (rash, itching, Quincke’s edema)
- Suicidal thoughts
- Mood swings
- Visual impairment
If serious side effects occur, stop taking the drug immediately and consult a doctor.
Can dapoxetine be taken with other medications?
Concomitant use of dapoxetine with certain medications is contraindicated or requires special caution.
It is strictly forbidden to take dapoxetine from:
- Monoamine oxidase inhibitors (MAOIs).
- Thioridazine.
- Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants and other drugs with serotonergic action.
- CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone).
Dapoxetine should be taken with caution from:
- CYP2D6 inhibitors (fluoxetine, paroxetine).
- Drugs that affect blood clotting.
- Drugs for the treatment of erectile dysfunction (sildenafil, tadalafil, vardenafil).
- Alcohol.
Before you start taking dapoxetine, be sure to tell your doctor about all the medications you take, including prescription and over-the-counter medications, vitamins, and nutritional supplements.
Who is recommended to buy generic Dapoxetine in the USA?
Generic Dapoxetine is recommended for men in the United States aged 18 to 64 years who:
- They suffer from premature ejaculation and strive to prolong the duration of sexual intercourse.
- They are looking for an effective, safe and affordable drug for the treatment of PE.
- Want to improve ejaculation control and enhance the quality of their sex life.
- They want to get rid of the psychological discomfort associated with the problem of PE.
You can buy generic Dapoxetine in online pharmacies that specialize in selling drugs for the treatment of sexual disorders. When choosing an online pharmacy, pay attention to its reputation, the presence of a license for pharmaceutical activity and customer reviews.
Remember that self-medication can be harmful to your health. Before starting to take generic Dapoxetine, be sure to consult your doctor!