- Home
- Products
- Dapoxetine
- DAPOXETINE+AVANAFIL
Dapoxetine+Avanafil: Double Action for Maximum Control and Confidence
Dapoxetine + Avanafil is a combination drug developed for men seeking a comprehensive solution to problems with erectile dysfunction (ED) and premature ejaculation (PE). The combination of two powerful active ingredients ensures simultaneous restoration of erection and prolongation of the duration of sexual intercourse.
Dapoxetine + Avanafil tablets what is it?
Dapoxetine + Avanafil is a combination drug available in the form of tablets for oral administration. Each tablet contains two active ingredients:
- Avanafil: Phosphodiesterase type 5 (PDE5) inhibitor. It blocks the action of the PDE5 enzyme, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the cavernous bodies of the penis. cGMP relaxes the smooth muscles of blood vessels, promoting blood flow and causing an erection. Avanafil, by blocking PDE5, increases the concentration of cGMP, providing a lasting erection with sexual stimulation. Avanafil has a rapid onset of action (after 15-30 minutes) and high selectivity of PDE5, which minimizes the risk of side effects.
- Dapoxetine: A short-acting selective serotonin reuptake inhibitor (SSRI). It delays the onset of ejaculation by increasing the concentration of serotonin in the nerve endings. This allows a man to better control the moment of ejaculation and prolong the duration of sexual intercourse .
The combination of avanafil and dapoxetine in one drug provides a complex effect on male sexual function, solving two problems at once: ED and PE.
What is the composition of Dapoxetine + Avanafil?
The composition of Dapoxetine + Avanafil tablets may vary slightly depending on the manufacturer, but usually includes:
- Avanafil: Most common dosages: 50 mg, 100 mg.
- Dapoxetine hydrochloride: Most common dosages: 30 mg, 60 mg, 100 mg.
- Excipients:
- Lactose monohydrate: filler.
- Microcrystalline cellulose: filler and binder.
- Crosscarmellose sodium: disintegrant.
- Hydroxypropyl cellulose: binder
- Silicon dioxide colloidal anhydrous: anti-caking agent.
- Magnesium stearate: lubricant.
- Hypromellose (hydroxypropyl methylcellulose): film-forming agent.
- Titanium dioxide (E171): white pigment.
- Triacetin/Macrogol: plasticizer.
- Dyes: May be added for identification.
Who is the manufacturer of Dapoxetine+Avanafil and what is a generic?
Combination drugs of Dapoxetine and Avanafil are usually generics . There are no original drugs containing this exact combination. Avanafil (trade name Stendra/Spedra) and Dapoxetine (trade name Priligy) are available as separate drugs.
A generic is a drug that contains the same active ingredient (or combination of ingredients), in the same dose, and in a similar dosage form as the original (brand) drug. Generics undergo rigorous bioequivalence testing to confirm that they are absorbed by the body in the same way as original drugs and provide an identical therapeutic effect.
Generic manufacturers of Dapoxetine + Avanafil combination are mainly Indian pharmaceutical companies such as:
- Sunrise Remedies Pvt. Ltd. (manufactures the drug under the name Top Avana).
- Centurion Laboratories
Why take Dapoxetine + Avanafil?
Dapoxetine + Avanafil is used to treat men who suffer from both erectile dysfunction (ED) and premature ejaculation (PE) .
- Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse.
- Premature ejaculation (PE) is a condition in which ejaculation occurs earlier than desired by a man or his partner, with minimal sexual stimulation (often before or immediately after penetration).
The drug helps to solve both problems, providing a strong erection and prolonged sexual intercourse.
How to take Dapoxetine+Avanafil?
The recommended dose and method of administration may vary depending on the specific product and the ratio of active ingredients. Always follow the instructions provided by the manufacturer and the recommendations of your doctor.
General recommendations:
- Take one tablet 30-60 minutes before expected sexual activity.
- The tablet should be swallowed whole with a sufficient amount of water.
- It is not recommended to take more than 1 tablet per day.
- The drug works only in the presence of sexual stimulation.
- Consuming alcohol and fatty foods may reduce the effectiveness and slow down the action of the drug.
What are the contraindications for Dapoxetine + Avanafil?
Dapoxetine + Avanafil has a number of contraindications associated with the action of both components:
- Hypersensitivity to avanaphyl, dapoxetine or any other component of the drug.
- Concomitant administration of nitrates in any form (nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, etc.).
- Concomitant use of nitric oxide donors (eg, amyl nitrite).
- Concomitant use of monoamine oxidase inhibitors (MAO) , as well as within 14 days after their withdrawal.
- Concomitant administration of thioridazine .
- Concomitant administration of strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir).
- Severe cardiovascular diseases in which sexual activity is not recommended (unstable angina, severe heart failure).
- Recently suffered a myocardial infarction (last 90 days).
- Recently suffered a stroke (within the last 6 months).
- Hereditary degenerative diseases of the retina , such as retinitis pigmentosa.
- Loss of vision in one eye due to non-arteritic anterior ischemic optic neuropathy (NAINO).
- Severe liver failure.
- Severe renal failure.
- Age up to 18 years and over 65 years.
- Female gender.
- Orthostatic hypotension has been diagnosed or suspected.
- Manic state or severe depression.
- History of suicidal thoughts or behavior.
Does Dapoxetine+Avanafil have any side effects?
Like any drug, Dapoxetine + Avanafil can cause side effects. Most often, they are associated with the action of avanafil and dapoxetine:
- Headache.
- Flushing of blood to the face.
- Nasal congestion.
- Dizziness.
- Nausea.
- Dyspepsia (indigestion).
- Diarrhea.
- Dry mouth.
- Insomnia or drowsiness.
- Anxiety, nervousness.
- Increased sweating.
- Back pain.
Less common may include:
- Changes in vision.
- Tinnitus.
- Tachycardia (rapid heartbeat).
- Increase or decrease in blood pressure.
- Decreased libido.
In very rare cases:
- Fainting.
- Orthostatic hypotension.
If serious side effects occur, especially those related to vision, hearing, cardiovascular system or mental state, you should stop taking the medicine immediately and consult a doctor.
Can Dapoxetine+Avanafil be taken with other medications?
Before you start taking Dapoxetine + Avanafil, be sure to tell your doctor about all the medications you are taking . This includes prescription and over-the-counter medications, as well as vitamins and herbal supplements.
It is strictly prohibited to take Dapoxetine + Avanafil at the same time:
- nitrates.
- Nitric oxide donors.
- MAO inhibitors.
- Thioridazine.
- Potent CYP3A4 inhibitors.
Should be taken with caution from:
- Alpha adrenergic blockers.
- Other drugs for the treatment of ED.
- CYP3A4 inhibitors and inducers.
- Antihypertensive drugs.
- Other SSRIs, SIZON and tricyclic antidepressants.
- Drugs that affect platelet function.
- Warfarin and other anticoagulants.
Who is recommended to buy generic Dapoxetine + Avanafil in the USA?
Generic Dapoxetine + Avanafil is recommended for purchase in the USA for men aged 18 years and older who:
- They suffer from both erectile dysfunction and premature ejaculation .
- They are looking for a fast-acting and effective combination drug.
- They want to improve the quality of their sex life and regain their confidence.
- They prefer the affordable price of generics.
Important: Dapoxetine + Avanafil is a prescription drug . Before purchasing and taking it, you must consult a doctor . The doctor will conduct an examination, establish a diagnosis, exclude contraindications and select the optimal dosage. It is recommended to buy the drug only in licensed pharmacies or trusted online stores to avoid purchasing counterfeits.
Conclusion
Dapoxetine + Avanafil is a combination drug that offers an effective solution for men who face problems with erectile dysfunction and premature ejaculation. Due to the rapid onset of action of avanfil and the prolonged effect of dapoxetine, this drug allows you to achieve a stable erection and significantly prolong sexual intercourse. However, like any drug, Dapoxetine + Avanafil has its contraindications and can cause side effects. Therefore, before starting to take it, be sure to consult a doctor and strictly follow his recommendations.